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Use of the product may enhance the nephrotoxic effect of blood substitutes such as dextran and sodium alginate, the use of which may cause renal disorders. It is advisable to avoid using the product concomitantly with these blood substitutes.
Respiratory depression due to curare-like effect (neuromuscular blocking effect) may occur. When the product is administered concomitantly with anesthetics or muscle relaxants, careful administration is required.
Concomitant use of the product with loop diuretics such as ethacrynic acid and furosemide may enhance nephrotoxicity and/or ototoxicity.
It is advisable to avoid using the product concomitantly with these diuretics.
